Met-Flox

Nomenclature

C57BL/6Smoc-Metem1(flox)Smoc

Cat. NO.

NM-CKO-200328

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Met

Synonyms

HGF， HGFR， Par4， c-Met， AI838057

NCBI ID

17295

MGI ID

96969

Ensembl ID

ENSMUSG00000009376

Pubmed

Met

Human Ortholog

MET

Model Description

These mice carry loxP sites flanking exon 16 of Met gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Met gene.

Disease Connection

Gilles De La Tourette Syndrome

Phenotype(s)

MGI:4950068
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mi56i-cre mice.

Reference(s)

Martins GJ, Shahrokh M, Powell EM, Genetic disruption of Met signaling impairs GABAergic striatal development and cognition. Neuroscience. 2011 Mar 10;176:199-209

Gestational Diabetes

Phenotype(s)

MGI:5504390
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pdx1-cre mice.

Reference(s)

Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, Garcia-Ocana A, Loss of HGF/c-Met signaling in pancreatic beta-cells leads to incomplete maternal beta-cell adaptation and gestational diabetes mellitus. Diabetes. 2012 May;61(5):1143-52

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