Stat3-Flox(2)

Nomenclature

C57BL/6Smoc-Stat3em1(flox)Smoc

Cat. NO.

NM-CKO-200225

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Stat3

Synonyms

Aprf; AW109958; 1110034C02Rik

NCBI ID

20848

MGI ID

103038

Ensembl ID

ENSMUSG00000004040

Pubmed

Stat3

Human Ortholog

STAT3

Model Description

These mice carry loxP sites flanking exon 18-20 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene.While Stat3-Flox(Stock No.NM-CKO-200050）mice carrying the loxP sites flanking exon 12-14 of Stat3 gene.
Research Application：Study on MicroRNA Correlation between FGFR1 Mutant Receptor Activation and Cardiac Hypertrophy

Disease Connection

inflammatory bowel disease

Phenotype(s)

MGI:2683230
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.

Reference(s)

Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY, Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med. 2003 Nov 17;198(10):1517-25

inflammatory bowel disease

Phenotype(s)

MGI:3783296
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.

Reference(s)

Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY, STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84

Peripartum Cardiomyopathy

Phenotype(s)

MGI:5906908
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.

Reference(s)

Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H, A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell. 2007 Feb 9;128(3):589-600

Inflammatory Bowel Disease

Phenotype(s)

MGI:4429499
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Csf1r-icre mice.

Reference(s)

Deng L, Zhou JF, Sellers RS, Li JF, Nguyen AV, Wang Y, Orlofsky A, Liu Q, Hume DA, Pollard JW, Augenlicht L, Lin EY, A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol. 2010 Feb;176(2):952-67

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