Ppp1r3a-KO

Nomenclature

C57BL/6Smoc-Ppp1r3aem1Smoc

Cat. NO.

NM-KO-200692

Strain State

Developing

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Gene Summary

Gene Symbol
Ppp1r3a

Synonyms

GM， RG1， RGL

NCBI ID

140491

MGI ID

2153588

Ensembl ID

ENSMUSG00000042717

Pubmed

Ppp1r3a

Human Ortholog

PPP1R3A

Model Description

Exon 4 of Ppp1r3a gene was deleted to generate Ppp1r3a knockout mice.

Disease Connection

Type 2 Diabetes Mellitus

Phenotype(s)

MGI:2653988

Reference(s)

Delibegovic M, Armstrong CG, Dobbie L, Watt PW, Smith AJ, Cohen PT, Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. Diabetes. 2003 Mar;52(3):596-604

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