Prox1-Flox

Nomenclature

C57BL/6Smoc-Prox1tm1(flox)Smoc

Cat. NO.

NM-CKO-2102305

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Prox1

Synonyms

PROX-1， A230003G05Rik

NCBI ID

19130

MGI ID

97772

Ensembl ID

ENSMUSG00000010175

Pubmed

Prox1

Human Ortholog

PROX1

Model Description

These mice carry loxP sites flanking exon 2 of Prox1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Prox1 gene.

Disease Connection

Dilated Cardiomyopathy

Phenotype(s)

MGI:5907122
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nkx2-5-Cre mice.

Reference(s)

Petchey LK, Risebro CA, Vieira JM, Roberts T, Bryson JB, Greensmith L, Lythgoe MF, Riley PR, Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9515-20

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